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Updated: Aug 13, 2026

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper (cTfh) Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
Published on: January 7, 2019
Primary cutaneous follicle center cell lymphoma
1Department of Dermatology, University of Graz, Austria. lorenzo.cerroni@kfunigraz.ac.at
Primary cutaneous follicle center cell lymphomas (FCCLs) are distinct from nodal lymphomas, often lacking typical markers like CD10 and Bcl-2. This review clarifies their unique features for accurate diagnosis.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Primary cutaneous follicle center cell lymphomas (FCCLs) present diagnostic challenges.
- Distinguishing FCCLs from nodal follicular lymphoma is crucial for appropriate treatment.
Purpose of the Study:
- To review the clinicopathologic, phenotypic, and molecular characteristics of primary cutaneous FCCLs.
- To provide diagnostic and differential diagnostic criteria for this specific cutaneous B-cell lymphoma variant.
Main Methods:
- Review of existing literature on primary cutaneous FCCLs.
- Comparison of features with nodal follicular lymphoma.
- Analysis of diagnostic markers including CD10, Bcl-2, and the t(14;18) translocation.
Main Results:
- Cutaneous FCCLs typically show a diffuse growth pattern, unlike the follicular pattern of nodal lymphoma.
- Neoplastic cells in FCCLs usually lack CD10 and Bcl-2 expression, and the t(14;18) translocation is absent.
- Nodal follicular lymphoma is characterized by CD10+, Bcl-2+ cells and the t(14;18) translocation.
Conclusions:
- Primary cutaneous FCCLs represent a distinct entity with unique clinicopathologic and molecular features.
- Accurate diagnosis relies on recognizing these differences and applying specific diagnostic criteria.
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