Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antiphospholipid thrombosis syndromes.

R L Bick1

  • 1University of Texas Southwestern Medical Center, and the Dallas Thrombosis/Hemostasis Clinical Center, USA. rbick@onramp.net

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|November 8, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contaminants in heparins continue to be unfolded.

International angiology : a journal of the International Union of Angiology·2008
Same author

The rheological changes after cesarean section: The influence of low molecular weight or unfractionated heparin on the rheological properties of blood.

Clinical hemorheology and microcirculation·2007
Same author

Stasis ulcers refractory to therapy--accelerated healing by treatment with clopidogrel +/- dalteparin: a preliminary report.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2001
Same author

Proficient and cost-effective approaches for the prevention and treatment of venous thrombosis and thromboembolism.

Drugs·2000
Same author

An update on heparins at the beginning of the new millennium.

Seminars in thrombosis and hemostasis·2000
Same author

Syndromes of disseminated intravascular coagulation in obstetrics, pregnancy, and gynecology. Objective criteria for diagnosis and management.

Hematology/oncology clinics of North America·2000
Same journal

Association of Protein C, but Not Protein S or Antithrombin With Ischemic Stroke: Bidirectional Two-Sample Mendelian Randomization and Meta-Analysis.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
Same journal

Risk Prediction Models for Deep Vein Thrombosis in Patients With Spontaneous Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
Same journal

Efficacy of an Integrated Nursing Protocol for the Management of Postoperative Upper Limb Circulatory Complications Following Transradial Coronary Intervention.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
Same journal

Dual-Channel Inhibition With Rivaroxaban and Aspirin for Thromboprophylaxis in Patients With Long-Term Inferior Vena Cava Filter Implantation: A Two-Center Cohort Study.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
Same journal

Association Between TNF-Alpha Levels and Atrial Fibrillation Outcomes: A Systematic Review and Meta-Analysis.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
Same journal

Interpretation of Prothrombin Time and Activated Partial Thromboplastin Time Mixing Studies Using Predefined Algorithms.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026
See all related articles

Antiphospholipid antibodies are linked to thrombosis, causing blood clotting disorders. Early diagnosis and specific treatments like LMWH or UH are crucial for preventing recurrent thrombotic events.

Area of Science:

  • Hematology
  • Immunology
  • Vascular Medicine

Background:

  • Antiphospholipid antibodies are a primary cause of acquired thrombotic disorders.
  • The exact mechanisms by which these antibodies induce a hypercoagulable state are still under investigation.
  • Antiphospholipid syndrome (APS) encompasses various thrombotic and obstetric complications.

Purpose of the Study:

  • To highlight the association between antiphospholipid antibodies and thrombosis.
  • To outline the different clinical presentations (syndromes I-VI) of APS.
  • To emphasize the importance of accurate diagnosis and appropriate management for secondary prevention.

Main Methods:

  • Review of clinical associations and diagnostic approaches for APS.
  • Assessment of different antibody types (IgG, IgA, IgM) and their clinical significance.

Related Experiment Videos

  • Evaluation of diagnostic tests including ELISA, dRVVT, hexagonal phospholipid neutralization, and beta-2-GP-I assays.

    • Main Results:

    • Anticardiolipin antibodies are associated with venous (Type I) and arterial (Type II) thrombosis, while lupus anticoagulant-associated thrombosis is typically venous.
    • Specific diagnostic tests are essential due to the unreliability of aPTT in affected patients.
    • Most APS patients do not respond well to warfarin or some antiplatelet therapies.

    Conclusions:

    • Prompt diagnosis of APS is critical for effective secondary prevention.
    • Treatment strategies should be tailored based on syndrome type and antibody profile.
    • Low molecular weight heparin (LMWH) or unfractionated heparin (UH) are often the most effective anticoagulants for APS-related thrombosis.