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Related Experiment Video

Updated: Jun 28, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

Association Between TNF-Alpha Levels and Atrial Fibrillation Outcomes: A Systematic Review and Meta-Analysis.

Alireza Fatemi1, Bahar Amirgholami2, Yasmin Yazdooei3

  • 1Department of Surgery, Surgery Research Center, School of Medicine, Rasool-E Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|June 26, 2026
PubMed
Summary

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This summary is machine-generated.

Elevated tumor necrosis factor-alpha (TNF-alpha) levels are significantly linked to atrial fibrillation (AF). This systematic review and meta-analysis confirms the association, highlighting inflammation

Area of Science:

  • Cardiology
  • Immunology
  • Biomarkers

Background:

  • Previous research suggests a connection between tumor necrosis factor-alpha (TNF-alpha) and atrial fibrillation (AF).
  • The precise nature of this relationship remains debated.
  • Inflammation is increasingly recognized as a factor in cardiovascular diseases.

Purpose of the Study:

  • To systematically review and meta-analyze existing evidence on the association between TNF-alpha levels and AF.
  • To assess the predictive value of TNF-alpha for AF.
  • To clarify the disputed relationship between TNF-alpha and AF.

Main Methods:

  • Comprehensive literature search across four databases and gray literature.
  • Systematic screening, quality assessment, and risk of bias evaluation of included studies.
Keywords:
atrial fibrillationmeta-analysissystematic reviewtumor necrosis factor-alpha

Related Experiment Videos

Last Updated: Jun 28, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

  • Meta-analysis of serum TNF-alpha levels using standardized mean difference (SMD) with random-effects model.

    • Main Results:

    • Twenty-three studies with 2,369 AF patients and 6,091 controls were included.
    • A significant positive association was found between elevated serum TNF-alpha levels and AF (SMD = 1.15, P = 0.0001).
    • Substantial heterogeneity (I² = 98.82%) and publication bias were noted across studies.

    Conclusions:

    • Elevated TNF-alpha levels are significantly associated with the presence of atrial fibrillation.
    • The findings support a role for inflammation in the pathophysiology of AF.
    • Further standardized research is needed to confirm these results and address heterogeneity.