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The Retina

The Retina

The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.

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Association Between Retinopathy and Systemic Sclerosis: A Systematic Review and Meta-Analysis.

Alireza Fatemi^1,2, Aylin Taghipour¹, Yasmin Yazdooei¹

¹Cardiovascular Surgery Research and Development Committee, Iran University of Medical Sciences (IUMS), Tehran, Iran.

International Journal of Rheumatic Diseases

|May 9, 2025

Summary

This summary is machine-generated.

This systematic review found no significant link between retinopathy and systemic sclerosis (SSc). Further research is needed to explore potential variations and SSc biomarkers.

Keywords:

meta‐analysis retinopathy systematic review systemic sclerosis

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Area of Science:

Ophthalmology
Rheumatology
Systemic Autoimmune Diseases

Background:

Systemic sclerosis (SSc) is an autoimmune disease with potential ocular manifestations.
The association between SSc and retinopathy requires further elucidation.
This study systematically reviews and meta-analyzes evidence on retinopathy in SSc patients.

Approach:

Conducted a comprehensive systematic search across multiple databases and gray literature.
Assessed the risk of bias in included studies using standardized tools.
Performed a meta-analysis using standardized mean difference (Std. Mean Difference) to quantify the association between retinopathy and SSc.

Key Points:

Twelve studies involving 359 SSc cases and 314 controls were included.
Meta-analysis of eight studies revealed a nonsignificant association (Std. Mean Difference = 0.08; p = 0.67) between SSc and retinopathy.
No significant publication bias was detected (p = 0.5362).

Conclusions:

Current evidence suggests no strong association between retinopathy and systemic sclerosis.
Subgroup analyses indicated potential variations but did not fully explain heterogeneity.
Larger, well-designed studies are warranted to investigate retinopathy as a potential SSc biomarker.