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Hemostasis in children with dysbacteriosis in chronic constipation

I V Kirgizov1, A M Sukhorukov, V A Dudarev

  • 1Krasnoyarsk State Medical Academy, The City's Clinical Hospital No. 20, The Department of Children Surgery of the Advanced Medical Courses, Russia. kirgizov@online.ru

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|November 8, 2001
PubMed

Insights

Children with chronic constipation show reduced beneficial bacteria, leading to pathogenic bacteria overgrowth and blood clotting issues. This dysbacteriosis impacts hemostasis, affecting coagulation factors and platelet function.

Area of Science:

  • Pediatric Gastroenterology
  • Hematology
  • Microbiology

Background:

  • Chronic constipation in children is often linked to gut dysbiosis.
  • The impact of dysbiosis on hemostasis in pediatric chronic constipation is not fully understood.

Purpose of the Study:

  • To investigate hemostasis disturbances in children with dysbacteriosis and chronic constipation.
  • To correlate changes in gut microbiota with specific hemostatic abnormalities.

Main Methods:

  • Analysis of blood coagulation factors (inner and outer mechanisms).
  • Assessment of prothrombin complex activity and vitamin K-dependent factors.
  • Evaluation of platelet function (thrombocytopathy, aggregation) and fibrinolysis.
  • Microbiological analysis to quantify colon bacillus and pathogenic microflora.

Main Results:

  • Reduced colon bacillus levels correlate with compensated and subcompensated chronic constipation.
  • Subcompensated and decompensated stages show increased pathogenic bacteria, hypocoagulation, thrombocytopathy, endotheliosis, and fibrinolysis inhibition.
  • Decompensated stages exhibit deficiencies in multiple coagulation factors (inner and outer pathways), microthrombosis, and vitamin K-dependent factor deficiency.

Conclusions:

  • Dysbacteriosis in pediatric chronic constipation leads to pathogenic bacterial overgrowth.
  • Hemostasis is significantly impaired, characterized by hypocoagulation, thrombocytopathy, endotheliosis, and fibrinolysis inhibition.
  • Vitamin K-dependent factor deficiency is a key factor in the observed coagulation disturbances.

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