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Total synthesis of epothilone B
M Valluri1, R M Hindupur, P Bijoy
1Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, P.O. Box 1848, University, Mississippi 38677-1848, USA.
Organic Letters
|November 9, 2001
Abstract:
[structure-see text] A convergent and stereoselective total synthesis of epothilone B (2) is described. The key steps are Normant reaction, Wadsworth-Emmons reaction of a methyl ketone 14 with the phosphonate reagent 7, diastereoselective aldol condensation of aldehyde 3 with enolate 4 to form the C6-C7 bond, and macrolactonization.