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Updated: Aug 5, 2026
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Prevalence of hypersensitivity to specific fungal allergens as determined by intradermal dilutional testing
R H Stroud1, K H Calhoun, S T Wright
1Department of Otolaryngology, The University of Texas Medical Branch, Galveston 77555, USA.
Objective:
To determine fungal allergen reactivity prevalence by intradermal dilutional testing in patients with and without chronic rhinitis or rhinosinusitis symptoms.
Study Design:
Prospective comparison of fungal allergen reactivity prevalence in symptomatic and asymptomatic patients.
Setting:
University medical center.
Methods:
Group I (chronic rhinitis and/or rhinosinusitis symptoms) and Group II (asymptomatic) patients underwent intradermal dilutional testing with usual and fungal allergens.
Results:
Fungal reactivity occurred in 65% (13/20) of Group I, and 13% (4/30) of Group II (P < 0.0002 by chi(2) testing). Group I was more reactive to non-fungal allergens (85% vs. 33%, p < 0.0004), and to all allergens considered together (95% vs. 40%, p < 0.0001).
Conclusions:
Patients with chronic rhinitis and rhinosinusitis symptoms were more reactive to fungal and nonfungal allergens. Fungal allergens were as likely as nonfungal to elicit reactivity.
Significance:
These findings suggest a role for fungal hypersensitivity in chronic rhinitis and chronic rhinosinusitis.
