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Tissue engineering: orthopedic applications.

C T Laurencin1, A M Ambrosio, M D Borden

  • 1Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA. Laurencin@drexel.edu

Annual Review of Biomedical Engineering
|November 10, 2001
PubMed
Summary

Tissue engineering offers a promising alternative for treating musculoskeletal disorders, addressing limitations of current donor tissue methods. This approach leverages engineering and biological principles for enhanced orthopedic repair.

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Area of Science:

  • Orthopedics
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Musculoskeletal disorders are a growing concern due to aging populations and sports injuries.
  • Current treatments using donor tissues face challenges like limited supply and immune rejection.
  • There is a need for advanced therapeutic alternatives in orthopedics.

Purpose of the Study:

  • To review current and emerging tissue engineering techniques for musculoskeletal disorders.
  • To explore the potential of tissue engineering in treating bone, ligament, and cartilage conditions.
  • To highlight tissue engineering as a superior alternative to traditional treatments.

Main Methods:

  • Review of existing literature on tissue engineering in orthopedics.
  • Analysis of novel tissue engineering strategies for bone, ligament, and cartilage repair.

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  • Discussion of the interdisciplinary approach combining engineering, biology, and chemistry.

    • Main Results:

    • Tissue engineering presents a viable alternative to donor tissue grafts.
    • It offers a potentially more effective treatment for various musculoskeletal conditions.
    • The field is rapidly advancing with new techniques and applications.

    Conclusions:

    • Tissue engineering holds significant promise for the future of orthopedic treatment.
    • It addresses the limitations of current therapies by providing on-demand, biocompatible solutions.
    • Further research and development in tissue engineering are crucial for clinical translation.