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Related Experiment Videos

Wire-bottom versus solid-bottom rodent caging issues important to scientists and laboratory animal science

D M Stark1

  • 1Bristol-Myers Squibb, Pharmaceutical Research Institute, Veterinary Sciences, P.O. Box 4000, D24-01, Princeton, New Jersey 08543-4000, USA.

Contemporary Topics in Laboratory Animal Science
|November 13, 2001
PubMed
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Wire-bottom cages are prevalent in toxicology labs, but regulatory shifts emphasize bedding. Switching to bedded cages presents significant cost implications for research programs.

Area of Science:

  • Laboratory animal science
  • Toxicology research
  • Regulatory compliance

Background:

  • Regulatory bodies like the National Research Council and AAALAC emphasize bedding availability in rodent cages.
  • This emphasis creates regulatory and accreditation challenges for toxicology laboratories.
  • Wire-bottom caging is currently prevalent in many US toxicology facilities.

Purpose of the Study:

  • To review the use of wire-bottom versus bedded caging in toxicology laboratories.
  • To assess the perceived benefits and issues associated with each caging type.
  • To evaluate the financial implications of switching caging systems.

Main Methods:

  • A survey of 12 US-based pharmaceutical and contract toxicology laboratories was conducted.
  • Data on current caging practices (wire-bottom vs. bedded) were collected.

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  • Literature review on animal preferences and cage-associated lesions was performed.

    • Main Results:

    • Over 80% of rodents in surveyed facilities were housed in wire-bottom cages in 1999.
    • Significant short-term and long-term costs are associated with transitioning to solid-bottom, bedded caging.
    • Literature review provides context on animal welfare and potential lesions related to caging type.

    Conclusions:

    • A shift from wire-bottom to bedded caging entails substantial financial considerations for toxicology programs.
    • Institutional Animal Care and Use Committee (IACUC) review is crucial when investigative staff select caging.
    • Balancing regulatory requirements, animal welfare, and economic factors is essential in caging decisions.