Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solid-phase acylating reagents in new format: macroporous polymer disks.

J A Tripp1, F Svec, J M Fréchet

  • 1Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720-1460, USA.

Journal of Combinatorial Chemistry
|November 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advances in kynurenine analysis.

Clinica chimica acta; international journal of clinical chemistry·2023
Same author

Automated continuous-flow in-syringe dispersive liquid-liquid microextraction of mono-nitrophenols from large sample volumes using a novel approach to multivariate spectral analysis.

Talanta·2019
Same author

Current state of bioanalytical chromatography in clinical analysis.

The Analyst·2018
Same author

Influence of Diet and Dehydroepiandrosterone on Hypothalamic Monoamine Neurotransmitters in Zucker Rats.

Nutritional neuroscience·2016
Same author

Dehydroepiandrosterone: A Nutritional Supplement with Actions in the Central Nervous System.

Nutritional neuroscience·2016
Same author

Investigating the Debate: Does DHEA Alter Food Intake?

Nutritional neuroscience·2016

New monolithic acylation resins were developed using functionalized polymer disks. These reusable resins efficiently convert amines to amides in flow-through systems, offering a stable and recoverable solution for chemical synthesis.

Area of Science:

  • Polymer Chemistry
  • Organic Synthesis
  • Materials Science

Background:

  • Acylation reactions are fundamental in organic synthesis.
  • Development of efficient and reusable solid-phase catalysts is crucial for sustainable chemistry.
  • Existing methods often face challenges with stability and recovery.

Purpose of the Study:

  • To prepare novel monolithic acylation resins in a disk format.
  • To investigate the efficiency and reusability of these resins for amine acylation.
  • To demonstrate their application in flow-through synthesis.

Main Methods:

  • Polymerization of chloromethylstyrene and divinylbenzene in a monolithic rod.
  • Functionalization of porous poly(chloromethylstyrene-co-divinylbenzene) disks.

Related Experiment Videos

  • Graft polymerization initiated by 4,4'-azobis(4-cyanovaleric acid).
  • Surface modification to create active phenolic moieties for acylation.

    • Main Results:

    • Successfully prepared polyethylene-encased porous polymer disks.
    • Graft polymerization yielded a swellable reactive polymer gel, preventing increased flow resistance.
    • Demonstrated efficient conversion of various amines to amides using the grafted disks.
    • Showcased the recovery and reuse of the acylation resin with consistent performance.

    Conclusions:

    • The novel monolithic acylation resins offer a robust and reusable platform for amine acylation.
    • The disk format and polymer gel layer enhance stability and efficiency in flow-through operations.
    • These resins represent a significant advancement in solid-phase synthesis for amide bond formation.