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Updated: Aug 9, 2026
Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
Published on: June 6, 2011
Trans-sodium crocetinate restores blood pressure, heart rate, and plasma lactate after hemorrhagic shock
L J Giassi1, M J Gilchrist, M C Graham
1Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904-4741, USA. jlg@virginia.edu
Background:
Trans-sodium crocetinate (TSC) has been shown to increase oxygen consumption during hemorrhagic shock. The current study was done to determine the effect of TSC on other parameters such as blood pressure, heart rate, blood pH, and lactate.
Methods:
A rat model of hemorrhagic shock was used, in which a constant volume of blood is removed.
Results:
TSC increased mean arterial blood pressure from a value (immediately after hemorrhage) of 35 mm Hg to a value of 75 mm Hg, and all treated animals survived. In contrast, blood pressure in control animals decreased, with most dying soon after the hemorrhage. TSC also lessened the tachycardia which resulted from the hemorrhage. Blood pH did not decrease as much when TSC was given, and plasma lactate levels were greatly reduced.
Conclusion:
It would appear that TSC is a promising initial treatment for hemorrhagic shock.
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