Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glucocorticoid-induced osteoporosis.

R S Weinstein1

  • 1Department of Internal Medicine, Division of Endocrinology/Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. weinsteinroberts@exchange.uams.edu

Reviews in Endocrine & Metabolic Disorders
|November 16, 2001
PubMed
Summary

Glucocorticoids disrupt bone remodeling by affecting osteoblast and osteoclast cell numbers and apoptosis. Therapies targeting apoptosis can restore bone mass and reduce fracture risk in glucocorticoid-induced osteoporosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Issues in modern bone histomorphometry.

Bone·2011
Same author

Spectroscopic markers of bone quality in alendronate-treated postmenopausal women.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2008
Same author

Telemedicine and telepresence for trauma and emergency care management.

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2008
Same author

Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density.

Endocrinology·2006
Same author

Histomorphometric evaluation of daily and intermittent oral ibandronate in women with postmenopausal osteoporosis: results from the BONE study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2004
Same author

Reversal of bone loss in mice by nongenotropic signaling of sex steroids.

Science (New York, N.Y.)·2002

Area of Science:

  • Bone Biology
  • Cellular Biology
  • Endocrinology

Background:

  • Bone remodeling relies on a balance between osteoblasts and osteoclasts.
  • Apoptosis (programmed cell death) regulates the lifespan of bone cells.
  • Glucocorticoids disrupt this balance, leading to bone loss.

Purpose of the Study:

  • To investigate the role of apoptosis in glucocorticoid-induced osteoporosis.
  • To explore therapeutic strategies targeting apoptosis for bone repair.

Main Methods:

  • Analysis of osteoblast and osteoclast precursor supply.
  • Assessment of mature osteoblast and osteocyte apoptosis.
  • Evaluation of cell number imbalance in glucocorticoid-induced osteoporosis.

Related Experiment Videos

Main Results:

  • Glucocorticoids decrease osteoblast and osteoclast precursor birth.
  • Increased apoptosis of mature osteoblasts and osteocytes is observed.
  • This disrupts the normal bone remodeling process.

Conclusions:

  • Altering apoptosis of osteoblasts and osteoclasts can correct cell number imbalances.
  • Targeting apoptosis offers a potential therapeutic approach for glucocorticoid-induced osteoporosis.
  • Restoring bone mass and reducing fracture risk are key outcomes.