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Updated: Oct 3, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

[Myocardial perfusion SPECT and isotopic ventriculography in obstructive and non-obstructive hypertrophic

G Romero-Farina1, J Candell-Riera, O Pereztol-Valdés

  • 1Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Revista Espanola De Medicina Nuclear
|November 16, 2001
PubMed

Insights

Myocardial perfusion SPECT and radionuclide ventriculography do not predict outcomes in hypertrophic cardiomyopathy (HC). However, non-reversible defects correlate with ECG changes and indicate potential progression to dilated cardiomyopathy.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Cardiovascular Imaging

Background:

  • Hypertrophic cardiomyopathy (HC) is a complex condition affecting the heart muscle.
  • Accurate prognostic tools are crucial for managing HC patients.

Purpose of the Study:

  • To assess the prognostic value of myocardial perfusion single-photon emission computed tomography (SPET) and radionuclide ventriculography in patients with HC.
  • To identify imaging markers associated with disease progression or adverse events.

Main Methods:

  • Exercise myocardial perfusion SPET with 99mTc-tetrofosmin and radionuclide ventriculography were performed in 101 HC patients.
  • Patients were followed for an average of 9.9 years, with a range of 1 to 28 years.

Main Results:

  • Thirty-six percent of patients showed perfusion defects (15% non-reversible, 21% reversible).
  • Non-reversible defects were more common in non-obstructive HC and associated with ECG abnormalities (pathologic Q waves), higher ventricular volumes, lower ejection fraction, and slower emptying velocity.
  • No imaging variable predicted mortality, pacemaker implantation, or myectomy; however, syncope was linked to higher ejection fraction.

Conclusions:

  • Myocardial perfusion SPET and radionuclide ventriculography lack prognostic value in HC.
  • Non-reversible perfusion defects may indicate progression towards a dilated form of HC.
  • Syncope in HC patients is associated with higher ejection fraction, but this finding lacks clear prognostic implication from the imaging modalities used.
Abstract

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