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Updated: Aug 8, 2026
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Models of Bone Metastasis
Published on: September 4, 2012
[Soft tissue malignant fibrous histiocytoma. Visualization in bone scintigraphy]
I Hervás Benito1, F Vera Espallardo, P Bello Arques
1Servicio de Medicina Nuclear, Hospital Universitario La Fe, Valencia, Spain. ihervas@inicia.es
Revista Espanola De Medicina Nuclear
|November 16, 2001
Summary
Malignant fibrous histiocytoma (MFH), a common soft tissue tumor, can show intense uptake on bone scintigraphy. This case highlights MFH avidly taking up 99mTc-MDP, contrary to typical findings.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Malignant fibrous histiocytoma (MFH) is a prevalent soft tissue sarcoma in adults.
- Diagnostic imaging of MFH often involves various modalities, with nuclear medicine playing a role.
Observation:
- A 73-year-old male patient diagnosed with MFH presented with intense hyperactive lesion in the blood pool phase of bone scintigraphy.
- The MFH demonstrated avid uptake of 99mTc-MDP in the late phase, a finding rarely reported.
Findings:
- This case contributes to the limited literature on MFH exhibiting significant 99mTc-MDP uptake.
- The study reviews existing MFH cases and diagnostic/follow-up techniques.
Implications:
- Highlights the variable avidity of MFH for radiopharmaceuticals like 99mTc-MDP.
- Suggests considering bone scintigraphy in the diagnostic workup and follow-up of MFH, particularly when intense uptake is observed.
