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Postantibiotic effects of antituberculosis agents alone and in combination
C Y Chan1, C Au-Yeang, W W Yew
1Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. chiuychan@cuhk.edu.hk
Antimicrobial Agents and Chemotherapy
|November 16, 2001
Summary
Rifampin showed the longest postantibiotic effect (PAE) against Mycobacterium tuberculosis. Combinations of first-line drugs demonstrated extended PAEs, offering insights into intermittent tuberculosis chemotherapy strategies.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Understanding postantibiotic effects (PAEs) is crucial for optimizing antimicrobial therapy.
- Mycobacterium tuberculosis requires effective treatment strategies, including intermittent chemotherapy.
Purpose of the Study:
- To evaluate the postantibiotic effects (PAEs) of seven antimycobacterial agents against Mycobacterium tuberculosis.
- To investigate the PAEs of these agents when used alone and in combination.
Main Methods:
- Radiometric culture system and viable count method were employed.
- Postantibiotic effects were assessed for seven antimycobacterial agents against Mycobacterium tuberculosis ATCC 27294.
- Agents were tested at peak serum concentrations, both individually and in combination.
Main Results:
- Rifampin exhibited the longest PAE (67.8 hours) among monotherapies.
- Combinations of first-line drugs demonstrated significantly longer PAEs, often exceeding 120 hours.
Conclusions:
- The study provides valuable data on the PAEs of antimycobacterial drugs.
- Findings support the scientific basis for intermittent antituberculosis chemotherapy regimens.