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Multidrug resistant Mycobacterium leprae from patients with leprosy
S Maeda1, M Matsuoka, N Nakata
1Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama-shi, Tokyo 189-0002, Japan.
Antimicrobial Agents and Chemotherapy
|November 16, 2001
Abstract:
Sequences of the folP1, rpoB, and gyrA genes were analyzed for 88 isolates of Mycobacterium leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines. Thirteen isolates (14.8%) showed representative mutations in more than two genes, suggesting the emergence of multidrug-resistant M. leprae.