Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Age-related changes in vestibular function: a longitudinal study.

R W Baloh¹, J Enrietto, K M Jacobson

¹Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095-1769, USA. rwbaloh@ucla.edu

Annals of the New York Academy of Sciences

|November 17, 2001

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

What Would We Do with All That Data? A Patient Perspective.

Ophthalmology. Glaucoma·2026

Same author

Population-Based Outcomes of Single-Fraction Stereotactic Ablative Radiotherapy for Early Stage Non-small Cell Lung Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026

Same author

Emerging protein sequencing technologies: proteomics without mass spectrometry?

Expert review of proteomics·2025

Same author

Multilingual tactical combat casualty care card: a combined Japanese self defense force and US military project.

BMJ military health·2024

Same author

Accuracy of machine learning in the preoperative identification of ovarian borderline tumors: a meta-analysis.

Clinical radiology·2024

Same author

Body mass index, weight change, and cancer prognosis: a meta-analysis and systematic review of 73 cohort studies.

ESMO open·2024

Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026

Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026

Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026

Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026

Same journal

Synchrony and Reciprocity in Rhythmic Interaction.

Annals of the New York Academy of Sciences·2026

Same journal

Leveraging Salt Fortification Platforms to Address Multiple-Micronutrient Deficiencies in Africa: A Policy Opportunity.

Annals of the New York Academy of Sciences·2026

See all related articles

Age-related changes in the vestibulo-ocular reflex (VOR) were studied longitudinally. Normal older subjects showed declining VOR function over time, unlike patients with stable bilateral vestibulopathy.

Area of Science:

Neuroscience
Gerontology
Ophthalmology

Background:

Cross-sectional studies suggest reduced vestibular function with age.
Longitudinal data on age-related vestibulo-ocular reflex (VOR) changes in humans is lacking.

Purpose of the Study:

To identify age-related changes in VOR in healthy older adults and patients with disequilibrium.
To conduct the first longitudinal study on age-related VOR decline.

Main Methods:

Measured VOR using step and sinusoidal stimuli in 57 healthy older adults over five yearly examinations.
Assessed 7 patients with severe bilateral vestibulopathy over the same period.
Analyzed VOR time constant, gain, and phase lead.

Main Results:

Related Experiment Videos

Normal subjects exhibited a shorter VOR time constant and decreased gain/increased phase lead in sinusoidal responses over time.
Visual-vestibular responses also showed decreased gain at low frequencies.
Bilateral vestibulopathy patients showed minimal VOR changes.

Conclusions:

This longitudinal study demonstrates age-related declines in VOR in healthy older adults.
These VOR changes were not linked to disequilibrium symptoms.
Stable bilateral vestibulopathy was observed in a subset of patients with disequilibrium.