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Mesalazine-induced pustular drug eruption.
K L Gibbon1, A P Bewley, K Thomas
1Department of Dermatology, Whipps Cross Hospital, London, United Kingdom.
Journal of the American Academy of Dermatology
|November 17, 2001
Summary
Mesalazine therapy can cause acute generalized eosinophilic pustuloderma, a rare skin condition. Prompt treatment with corticosteroids and stopping mesalazine led to patient recovery.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Mesalazine is a common treatment for inflammatory bowel disease.
- Adverse drug reactions can manifest in various ways, including dermatological conditions.
Observation:
- A patient developed acute generalized eosinophilic pustuloderma.
- The condition appeared during mesalazine therapy.
Findings:
- The pustuloderma was directly linked to mesalazine administration.
- Discontinuation of mesalazine and systemic corticosteroid treatment resulted in resolution.
Implications:
- This case highlights a previously undescribed adverse reaction to mesalazine.
- Clinicians should consider mesalazine as a potential cause of eosinophilic pustuloderma.