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Voltage-dependent calcium channels--beyond dihydropyridine antagonists
T P Snutch1, K G Sutton, G W Zamponi
1Biotechnology Laboratory, University of British Columbia, Vancouver, Canada. snutch@zoology.ubc.ca
Current Opinion in Pharmacology
|November 20, 2001
Abstract:
The blockade of L-type calcium channels by dihydropyridines, phenylalkylamines and benzothiazepines has been well described and forms the basis of a multibillion dollar market for the treatment of cardiovascular disease and migraine. More recently, neuron-specific calcium channels have become the subject of intense interest regarding their potential as therapeutic targets for the treatment of chronic and neuropathic pain. A number of recently described agents that selectively target neuronal calcium channels have been described and appear promising for a variety of pain conditions.