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Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
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Heterodimerization of G-protein-coupled receptors in the CNS

F H Marshall1

  • 1Molecular Pharmacology Department, GlaxoWellcome Research and Development, Stevenage, Hertfordshire, UK. fhm27375@glaxowellcome.co.uk

Current Opinion in Pharmacology
|November 20, 2001
PubMed

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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