Related Experiment Video
Updated: Jun 21, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
Molecular insight develops our understanding of the GABA(B) receptor
1Molecular Pharmacology Department, Glaxo Wellcome Research and Development, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK. fhm27375@glaxowellcome.co.uk
Abstract:
The GABA(B) receptor has been cloned and shown to consist of a heterodimer of two 7-transmembrane receptor subunits. Cloning of the receptor has allowed detailed analysis of the pharmacology in recombinant assays and has also generated a range of high-throughput functional assays suitable for compound screening. Detailed analysis of the distribution of the receptor at the mRNA and protein level has also been completed. As yet, no molecular subtypes of the receptor have been identified and the challenge for drug development remains the identification of compounds with desired therapeutic benefit combined with a low side effect profile.
More Related Videos
07:51Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
Published on: November 14, 2014
11:57Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking
Published on: March 28, 2014
Related Concept Videos
Ligand-Gated Ion Channel Receptor: Gating Mechanism
G Protein-coupled Receptors
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
G Protein-coupled Receptors
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
The Two-State Receptor Model
The binding affinity of a drug determines its interaction with one...
G-protein Coupled Receptors
G-protein Coupled Receptors