Related Experiment Video
Updated: Aug 8, 2026

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses
Published on: July 7, 2017
Interleukin-8 receptor antagonists in pulmonary diseases
1Respiratory, Inflammation and Respiratory Pathogens Center for Excellence in Drug Discovery, GlaxoSmithKline, King of Prussia, PA 19406, USA. douglas_w_hay@sbphrd.com
Controlling inflammatory cell recruitment in the lung is a promising therapeutic strategy for pulmonary diseases. Interleukin-8 (IL-8) receptor antagonists may help understand IL-8
Area of Science:
- Pulmonary medicine
- Immunology
- Pharmacology
Background:
- Inflammatory cells play a key role in the development of lung diseases.
- Interleukin-8 (IL-8) and related CXC chemokines are crucial for neutrophil and T cell function.
- These chemokines are implicated in the pathophysiology of various pulmonary conditions.
Purpose of the Study:
- To investigate the role of IL-8 and related chemokines in lung disease.
- To explore the therapeutic potential of targeting IL-8 receptors.
Main Methods:
- Identification of small-molecule antagonists for IL-8 receptors.
- Utilizing these antagonists to study chemokine involvement in lung pathophysiology.
Main Results:
- Small-molecule antagonists of IL-8 receptors have been successfully identified.
- These antagonists provide tools to investigate the role of IL-8 in lung diseases.
Conclusions:
- Targeting IL-8 receptors with small-molecule antagonists is a viable strategy.
- Further research using these antagonists can elucidate the pathophysiology of lung diseases.
More Related Videos
09:00Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
Published on: June 24, 2020
10:21Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
Published on: September 20, 2024
Related Concept Videos
Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Antiasthma Drugs: β2-Adrenoceptor Agonists
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
Antiasthma Drugs: Muscarinic Receptor Antagonists
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...