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Related Experiment Videos

Eotaxin and asthma.

J E Pease1, T J Williams

  • 1Division of Biomedical Sciences, Imperial College School of Medicine, London, UK. j.pease@ic.ac.uk

Current Opinion in Pharmacology
|November 20, 2001
PubMed
Summary
This summary is machine-generated.

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Eotaxin, a protein found in asthmatic lungs, attracts eosinophils. New compounds block the eotaxin receptor CCR3, potentially leading to drugs that prevent lung inflammation.

Area of Science:

  • Immunology
  • Pharmacology

Background:

  • Eotaxin is a CC chemokine produced in asthmatic lungs.
  • It chemoattracts eosinophils by binding to the CC chemokine receptor CCR3 on leukocytes.
  • Eosinophil activation in lung tissue contributes to asthma pathogenesis.

Purpose of the Study:

  • To investigate the potential of blocking the CCR3 receptor for asthma treatment.
  • To explore the development of orally available drugs targeting eosinophil recruitment.

Main Methods:

  • Development of three low molecular weight compounds.
  • These compounds are designed to block the CC chemokine receptor CCR3.

Main Results:

  • Three novel low molecular weight compounds targeting CCR3 have been developed.

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  • These compounds show potential for blocking eosinophil migration.

    • Conclusions:

    • Blocking the eotaxin-CCR3 interaction is a promising therapeutic strategy for asthma.
    • Further development could lead to orally available drugs for preventing eosinophilic lung inflammation.