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The mitochondrial genome and mitochondrial muscle disorders
A M Schaefer1, R W Taylor, D M Turnbull
1Mitochondrial Research Group, School of Neurosciences and Psychiatry, The Medical School, University of Newcastle-upon-Tyne, UK.
Current Opinion in Pharmacology
|November 20, 2001
Abstract:
Mitochondrial disorders represent a multitude of clinically heterogeneous diseases in which the genetic abnormality can involve either a mitochondrial or nuclear gene. In addition to inherited defects, somatic mitochondrial DNA mutations have been implicated in the pathogenesis of neurodegenerative disease, cancer and the ageing process. The recent emergence of the first mouse models of mitochondrial disease will provide valuable insights into disease mechanisms and aid the development of realistic therapeutic strategies.