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Updated: Aug 6, 2026

Combined DNA-RNA Fluorescent In situ Hybridization (FISH) to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
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Published on: June 14, 2014

Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells

S Luikenhuis1, A Wutz, R Jaenisch

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Molecular and Cellular Biology
|November 20, 2001
PubMed
Summary

Antisense Tsix transcript is crucial for random X inactivation in mammals. Disrupting Tsix transcription leads to nonrandom X chromosome inactivation, establishing its regulatory role.

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