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Tcf4 can specifically recognize beta-catenin using alternative conformations

T A Graham1, D M Ferkey, F Mao

  • 1Department of Biological Structure, University of Washington, Seattle, Washington 98195, USA.

Nature Structural Biology
|November 20, 2001
PubMed
Summary

Beta-catenin accumulation drives colon cancer by activating Tcf4. This study reveals the crystal structure of the beta-catenin-Tcf4 complex, identifying key interactions for potential drug development targeting cancer proliferation.

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