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Correction of lymph circulation during immediate hypersensitivity reaction
M M Minnebaev1, F I Mukhutdinova, L G Zakharova
1Kazan State Medical University.
Bulletin of Experimental Biology and Medicine
|November 20, 2001
Summary
Norepinephrine and hydrocortisone therapy in dogs with anaphylactic shock improved lymph circulation. This enhanced the removal of metabolic products and stimulated vital exchange processes during allergic reactions.
Area of Science:
- Physiology
- Immunology
- Pharmacology
Background:
- Anaphylactic shock is a severe allergic reaction with complex physiological consequences.
- Lymphatic system dysfunction can impair the resolution of allergic inflammation.
- Therapeutic interventions aim to restore homeostasis during anaphylaxis.
Purpose of the Study:
- To investigate the impact of norepinephrine and hydrocortisone on lymph flow during anaphylactic shock.
- To evaluate the role of enhanced lymphatic circulation in managing allergic alterations.
Main Methods:
- Lymph flow rate was measured in the thoracic lymphatic duct of dogs.
- Dogs experienced experimentally induced anaphylactic shock.
- Mono- or combination therapy with norepinephrine and hydrocortisone was administered.
Main Results:
- Therapy with norepinephrine and hydrocortisone intensified lymph circulation.
- Improved lymph flow enhanced the resorption and transport of metabolic products.
- Stimulated exchange processes in blood and tissues were observed during allergic alterations.
Conclusions:
- Norepinephrine and hydrocortisone therapy positively influences lymphatic function during anaphylactic shock.
- Enhancing lymph circulation is a potential therapeutic strategy for managing anaphylaxis.
- Restoration of lymphatic transport aids in resolving metabolic disturbances in allergic conditions.