Oligonucleotides--from design to the clinic

Combinatorial ASO-mediated therapy with low dose SMN and the protective modifier Chp1 is not sufficient to ameliorate SMA pathology hallmarks.

Neurobiology of disease·2022

Pharmacology of antisense therapeutic agents : cancer and inflamination.

Methods in molecular medicine·2011

Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma.

Leukemia·2004

Cytosolic delivery of antisense oligonucleotides by listeriolysin O-containing liposomes.

Gene therapy·2003

The CATH database: an extended protein family resource for structural and functional genomics.

Nucleic acids research·2003

ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease.

Gut·2002

Gene therapy: Have the risks associated with viral vectors been solved?

Current opinion in molecular therapeutics·2011

Teduglutide, a glucagon-like peptide-2 analog for the treatment of gastrointestinal diseases, including short bowel syndrome.

Current opinion in molecular therapeutics·2010

Dulaglutide, a long-acting GLP-1 analog fused with an Fc antibody fragment for the potential treatment of type 2 diabetes.

Current opinion in molecular therapeutics·2010

Corticorelin, a synthetic human corticotropin-releasing factor analog, for the treatment of peritumoral brain edema.

Current opinion in molecular therapeutics·2010

Mogamulizumab, a humanized mAb against C-C chemokine receptor 4 for the potential treatment of T-cell lymphomas and asthma.

Current opinion in molecular therapeutics·2010

Gevokizumab, an anti-IL-1β mAb for the potential treatment of type 1 and 2 diabetes, rheumatoid arthritis and cardiovascular disease.

Current opinion in molecular therapeutics·2010

Magneto-NIR-II-Programmed Cascade Nanozymes Unlocking Blood-Brain Barrier Translocation and Autophagic Resistance in Glioblastoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host-Directed Strategies.

Medicinal research reviews·2026

Mul-PheG2P: decoupled learning and prediction-space fusion enables robust and interpretable multi-phenotype genomic prediction.

The New phytologist·2026

Multi-Institutional Development and Validation of a Nomogram Based on New Microvascular Ultrasound Techniques to Predict the Severity of Renal Fibrosis in Chronic Kidney Disease.

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine·2026

The Application of the Balloon Pre-Inflating Technique in Percutaneous Balloon Compression for Primary Trigeminal Neuralgia: A Retrospective Study.

Pain physician·2026

Phage as a prospective arsenal against superbugs.

Molecular biology reports·2026

Related Experiment Videos

Oligonucleotides--from design to the clinic

Related Concept Videos

Combinatorial ASO-mediated therapy with low dose SMN and the protective modifier Chp1 is not sufficient to ameliorate SMA pathology hallmarks.

Pharmacology of antisense therapeutic agents : cancer and inflamination.

Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma.

Cytosolic delivery of antisense oligonucleotides by listeriolysin O-containing liposomes.

The CATH database: an extended protein family resource for structural and functional genomics.

ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease.

Gene therapy: Have the risks associated with viral vectors been solved?

Teduglutide, a glucagon-like peptide-2 analog for the treatment of gastrointestinal diseases, including short bowel syndrome.

Dulaglutide, a long-acting GLP-1 analog fused with an Fc antibody fragment for the potential treatment of type 2 diabetes.

Corticorelin, a synthetic human corticotropin-releasing factor analog, for the treatment of peritumoral brain edema.

Mogamulizumab, a humanized mAb against C-C chemokine receptor 4 for the potential treatment of T-cell lymphomas and asthma.

Gevokizumab, an anti-IL-1β mAb for the potential treatment of type 1 and 2 diabetes, rheumatoid arthritis and cardiovascular disease.

Magneto-NIR-II-Programmed Cascade Nanozymes Unlocking Blood-Brain Barrier Translocation and Autophagic Resistance in Glioblastoma.

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host-Directed Strategies.

Mul-PheG2P: decoupled learning and prediction-space fusion enables robust and interpretable multi-phenotype genomic prediction.

Multi-Institutional Development and Validation of a Nomogram Based on New Microvascular Ultrasound Techniques to Predict the Severity of Renal Fibrosis in Chronic Kidney Disease.

The Application of the Balloon Pre-Inflating Technique in Percutaneous Balloon Compression for Primary Trigeminal Neuralgia: A Retrospective Study.

Phage as a prospective arsenal against superbugs.

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Oligonucleotides--from design to the clinic

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