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An inexpensive mouse headholder suitable for optical recordings.

H U Fried1, H D Linnig, S I Korsching

  • 1Institute for Genetics, University of Cologne, Zuelpicher Str. 47, 50674 Cologne, Germnay. a2756552@smail.rrz.uni-koeln.de

Physiology & Behavior
|November 21, 2001
PubMed
Summary

A new, affordable mouse headholder offers stable, long-term head fixation for various ages. This versatile device enables direct head access for surgery and olfactory system studies using optical recording.

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Area of Science:

  • Neuroscience
  • Surgical Instrumentation
  • Animal Models

Background:

  • Reliable head fixation is crucial for long-term neuroscience experiments in mice.
  • Existing head fixation methods can be expensive or limit experimental approaches.

Purpose of the Study:

  • To design and present an inexpensive headholder for mice.
  • To enable reliable, long-term head fixation for diverse experimental applications.

Main Methods:

  • Development of a novel, cost-effective mouse headholder design.
  • Testing the headholder's compatibility with both upright and inverted microscopes.
  • Evaluating the headholder's suitability for surgery and olfactory system stimulation.

Main Results:

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  • The headholder provides reliable head fixation for mice from 3 weeks old to adulthood.
  • Its design allows direct dorsal and ventral head access.
  • The apparatus facilitates surgery, olfactory system stimulation, and optical recording without a nose clamp.

Conclusions:

  • This inexpensive headholder is a versatile tool for neuroscience research.
  • It supports various experimental procedures, including optical recording and olfactory system manipulation.
  • The design overcomes limitations of existing head fixation devices.