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[Protective effect of tanshinone IIA on acute hepatic injury in mice]
Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials
|November 22, 2001
Abstract
Objective:
To study the effect of tanshinone IIA on two models of acute hepatic injury in mice.
Methods:
Two acute hepatic injury models induced by carbon tetrachloride (CCl4) and D-galactosamine (D-GalN) in mice were used. ALT, AST in serum and MDA in liver homogenate were used as indexes.
Results:
Tanshinone IIA (10 mg.kg-1, 20 mg.kg-1, 30 mg.kg-1), similar to biophenyldicarboxylate, could decrease ALT, AST in serum and MDA in hepatic homogenate on acute hepatic injury induced by CCl4 and D-GalN.
Conclusion:
Tanshinone IIA possessed obvious protective effect against liver injury induced by CCl4 or D-GalN.
