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Related Experiment Videos

[Present status and perspectives on antimycotics with systemic effects].

J Haber1

  • 1I. interní klinika 1. LF UK a VFN, Praha. haber@mbox.cesnet.cz

Casopis Lekaru Ceskych
|November 22, 2001
PubMed
Summary
This summary is machine-generated.

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Antimycotic treatments for systemic mycoses are limited. Newer antifungal agents are being developed to combat resistance and improve safety, with novel drugs in clinical trials.

Area of Science:

  • Mycology and infectious diseases.
  • Pharmacology of antifungal agents.

Context:

  • The current spectrum of antimycotics for systemic mycoses is limited.
  • Amphotericin B (AmB) is the historical gold standard but has significant nephrotoxicity.
  • Lipid formulations of AmB reduce toxicity but are expensive.

Purpose:

  • To review the current landscape of antifungal agents for systemic mycoses.
  • To discuss the limitations of existing treatments and the development of novel antifungals.
  • To explore emerging drug classes targeting different mechanisms and resistance pathways.

Summary:

  • Amphotericin B remains a key agent, but its toxicity is a concern, partially addressed by lipid formulations.
  • Azoles, particularly third-generation triazoles like voriconazole, posaconazole, and ravuconazole, offer broader spectrum activity, including against Aspergillus infections.

Related Experiment Videos

  • Future therapies include echinocandins, sordarins, pradimicins, and efflux pump inhibitors, with many in advanced clinical trials.

    • Impact:

    • Highlights the need for safer and more effective antifungal therapies.
    • Identifies promising new drug classes to address the growing challenge of antifungal resistance.
    • Provides an overview of the pipeline for novel systemic antifungal treatments.