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Therapeutic mammalian artificial episomal chromosomes

J M Vos1

  • 1Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, 27599-7295, USA. vos@med.unc.edu

Current Opinion in Molecular Therapeutics
|November 22, 2001
PubMed
Summary

Mammalian artificial chromosomes (MACs) are engineered using two main strategies for gene therapy. These methods offer distinct advantages for therapeutic vector development and creating transgenic animals.

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