Related Experiment Video
Updated: Jul 16, 2026
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Pyrazolopyrimidines
1University of Western Ontario, London Health Sciences Centre, Victoria Campus, 375 South Street, London, Ontario, Canada N6A 4G5. cgeorge@uwo.ca
Abstract:
Pharmacological therapy has an important role in the management of insomnia. Although older drugs are highly effective for initiating and maintaining sleep, tolerance and withdrawal effects as well as impairment of daytime performance are commonly troublesome and limit their use. Aided by increased knowledge of gamma-aminobutyric acid (GABA) and its receptors, new hypnotic sedatives have been developed that are increasingly selective for the various subunits of the GABA receptor. This development has produced newer agents with very favourable hypnotic profiles and side-effect profiles that provide better treatment options for medical practitioners. The pyrazolopyrimidines, the latest in this area, seem to offer some advantages over other agents.
Related Concept Videos
Five-Membered Heterocyclic Aromatic Compounds: Overview
Basicity of Heterocyclic Aromatic Amines
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Nomenclature of Aryl and Heterocyclic Amines
Biosynthesis of Nucleic Acids
Antiviral Nucleoside Inhibitors

