Related Experiment Video
Updated: Aug 9, 2026

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage
Published on: April 23, 2017
Three-point Dixon chemical-shift imaging for evaluating articular cartilage defects in the knee joint on a
M A Bredella1, C Losasso, S C Moelleken
1Department of Radiology, University of California, 505 Parnassus Ave, San Francisco, CA 94143-0628, USA.
Objective:
The purpose of our study was to assess the value of a modified three-point Dixon MR technique for evaluating articular cartilage defects in the knee joint on a low-field-strength open magnet, correlated with arthroscopy.
Subjects And Methods:
Twenty consecutive patients who underwent both MR imaging and arthroscopy of the knee joint for suspected internal derangement were examined. A modified three-point Dixon MR sequence with a single radiofrequency echo single-scan method for water and fat separation with correction of the static field inhomogeneities was performed on a 0.35-T open magnet to obtain fat suppression. The MR images were prospectively evaluated for the presence and grade of articular cartilage defects.
Results:
Uniform fat suppression was obtained in all patients using the modified three-point Dixon technique. Fifty-nine cartilage abnormalities were identified in 19 patients on the basis of arthroscopy. Forty-seven of 59 arthroscopically proven abnormalities were prospectively detected on MR imaging. Compared with arthroscopy, the overall sensitivity of the modified three-point Dixon technique in detecting cartilage lesions was 80% and the specificity was 73%. Sixty-five percent of the cartilage abnormalities were graded identically on MR imaging and arthroscopy.
Conclusion:
The modified three-point Dixon sequence is a useful technique for achieving fat suppression in the knee joint on a 0.35-T open magnet. It is a sensitive and specific technique for the assessment of cartilage abnormalities in the knee.
Related Concept Videos
π Electron Effects on Chemical Shift: Overview
Magnetic Resonance Imaging

