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Central liponeurocytoma.

D H George1, B W Scheithauer

  • 1Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

The American Journal of Surgical Pathology
|November 22, 2001
PubMed
Summary
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Cerebellar liponeurocytoma, a glioneuronal tumor, exhibits biphasic cells and occurs in older adults. Ultrastructural examination reveals tumoral lipidization, not adipose metaplasia, in these neurocytic neoplasms.

Area of Science:

  • Neuropathology
  • Central Nervous System Tumors
  • Glioneuronal Neoplasms

Background:

  • The World Health Organization (2000) classified cerebellar liponeurocytoma as a glioneuronal tumor.
  • Previously considered a medulloblastoma variant (medullocytoma), its indolent behavior and morphology warranted reclassification.
  • This tumor presents a biphasic morphology with neurocytic and lipidized cells.

Observation:

  • Liponeurocytomas occur in older adults and generally have a favorable prognosis.
  • The term 'cerebellar' can be misleading, as similar neoplasms appear in other CNS locations, including the ventricles.
  • This study presents a third case of a liponeurocytoma, the first examined ultrastructurally.

Findings:

  • Ultrastructural analysis demonstrated progressive accumulation and coalescence of lipid vacuoles within cells retaining neurocytic features.

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  • The observed changes indicate tumoral lipidization as the underlying mechanism.
  • This contrasts with true adipose metaplasia, suggesting a distinct neoplastic process.

    • Implications:

    • Clarifies the histogenesis of liponeurocytomas, emphasizing tumoral lipidization over metaplasia.
    • Highlights the potential for these tumors to occur outside the cerebellum, broadening diagnostic considerations.
    • Provides ultrastructural evidence crucial for accurate diagnosis and classification of glioneuronal tumors.