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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: Jun 18, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
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The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

Papillary Renal Neoplasm With Reverse Polarity Is a Distinct Distal Nephron-Derived Tumor With Unique Methylation

Kyung Park1, Yuxiu Wang1, Kisong Kim1

  • 1Departments of Pathology.

The American Journal of Surgical Pathology
|June 16, 2026
PubMed
Summary

Papillary renal neoplasm with reverse polarity (PRNRP) is a distinct kidney cancer subtype. Its unique epigenetic profile, including KRAS mutations, separates it from other renal tumors and suggests distal nephron origins.

Keywords:
DNA methylationGATA3distal nephronpapillary renal neoplasm with reverse polarity (PRNRP)renal cell carcinoma

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Last Updated: Jun 18, 2026

The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
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Published on: January 22, 2013

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Published on: January 31, 2025

Area of Science:

  • Urology
  • Oncology
  • Molecular Biology

Background:

  • Papillary renal neoplasm with reverse polarity (PRNRP) is a proposed distinct renal cell neoplasm subtype.
  • PRNRP is characterized by KRAS mutations and indolent behavior.
  • The epigenetic landscape of PRNRP remains largely uncharacterized.

Purpose of the Study:

  • To investigate the epigenetic profile of PRNRP.
  • To determine the molecular characteristics and potential origin of PRNRP.
  • To differentiate PRNRP from other renal cell tumor subtypes.

Main Methods:

  • Targeted next-generation sequencing for driver mutations in 13 PRNRP cases.
  • Illumina MethylationEPIC array profiling of 11 PRNRP cases.
  • Comparison with a reference cohort of 71 common renal cell tumors.

Main Results:

  • KRAS mutations were identified in 92% of PRNRP cases.
  • PRNRPs formed a distinct epigenetic group, separate from papillary renal cell carcinomas (pRCCs).
  • Methylation data suggested PRNRP originates from the distal nephron, unlike pRCC from proximal tubules.

Conclusions:

  • PRNRP possesses a distinct epigenetic signature.
  • PRNRP is a unique subtype of renal cell neoplasm.
  • PRNRP likely originates from distal nephron cells.