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Left ventricular ejection fraction calculated from gated technetium-99-sestamibi SPECT.

J A van Staden1, C P Herbst, A van Aswegen

  • 1Department of Medical Physics, University of the Free State, Bloemfontein.

Cardiovascular Journal of South Africa : Official Journal for Southern Africa Cardiac Society [And] South African Society of Cardiac Practitioners
|November 22, 2001
PubMed
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The area under the polar graph (APC) method accurately calculates left ventricular ejection fraction (LVEF) from gated SPECT (GSPECT) images. This technique offers a reliable and reproducible alternative for assessing cardiac function.

Area of Science:

  • Nuclear cardiology
  • Cardiac imaging analysis
  • Quantitative cardiovascular assessment

Background:

  • Accurate left ventricular ejection fraction (LVEF) calculation is crucial for assessing cardiac function.
  • Left ventricular ejection fraction (LVEF) accuracy depends on precise end-diastolic volume (EDV) and end-systolic volume (ESV) determination.
  • Traditional methods for EDV and ESV calculation can be limited by image quality and analysis subjectivity.

Purpose of the Study:

  • To evaluate the feasibility of calculating EDV, ESV, and LVEF using the area under the polar graph (APC) method.
  • To assess the accuracy and reproducibility of the APC method for LVEF determination from gated single-photon emission computed tomography (GSPECT) images.
  • To compare LVEF results obtained by the APC method with conventional planar equilibrium radionuclide ventriculography (ERNV).

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Main Methods:

  • Technetium-99m ((99m)Tc) sestamibi GSPECT and planar ERNV were performed on 15 male subjects.
  • LV short-axis slices were reconstructed from GSPECT images.
  • LV edge points were determined using the APC method, with areas calculated via polar coordinates, interpolation, and numerical integration.

Main Results:

  • The APC method successfully determined LV edges in all 15 patients.
  • LVEF calculated using the APC method showed strong correlation with conventional ERNV (r = 0.96).
  • The APC method demonstrated good reproducibility for LVEF determination (intra-observer r = 0.99, inter-observer r = 0.99).

Conclusions:

  • The APC method enables easy and accurate LVEF determination with minimal mathematical assumptions.
  • The interpolation capability of the APC method ensures stable edge detection, even in areas of hypoperfused myocardium.
  • The APC method is a reliable tool for quantitative LVEF assessment in GSPECT imaging.