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Updated: Aug 4, 2026

Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders
Published on: September 4, 2011
[Analysis of Myc gene family in laryngeal cancer]
1Department of Otolaryngology Head and Neck Surgery, First Teaching Hospital, Norman Bethune University of Medical Sciences, Changchun 130021.
Objective:
To study the abnormal amplification and role of Myc gene family in the development of laryngeal cancer.
Method:
A PCR-PAGE-Laser scanning technique was applied.
Results:
There was no Myc gene amplification in the normal laryngeal tissues. The abnormal L-myc and C-myc gene were positive in 47% (15/32) of laryngeal cancers and 41% (13/32) of the cancers shown the N-myc gene amplification. Myc gene amplification was not related to age, sex and differentiation (P > 0.05), but the N-myc amplification was higher in patients with lymph node metastasis (P < 0.05).
Conclusion:
The N-myc amplification may play a role of positive regulation in the lymph metastasis of laryngeal cancer. The abnormal amplification of Myc gene family is one of the causes in development of laryngeal cancer.
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