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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
[Lysozyme and lactoferrin in human uncinate process mucosa during chronic sinusitis]
1Affiliated Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730.
Zhonghua Er Bi Yan Hou Ke Za Zhi
|November 23, 2001
Summary
Lysozyme (LZ) and lactoferrin (LF) show increased activity in the uncinate process mucosa during chronic sinusitis. This suggests these proteins play a role in the local defense mechanism against the condition.
Area of Science:
- Immunology
- Otorhinolaryngology
- Biochemistry
Context:
- Chronic sinusitis affects the uncinate process mucosa.
- Lysozyme (LZ) and lactoferrin (LF) are key immune proteins.
- Understanding local mucosal defense is crucial.
Purpose:
- To investigate the role of lysozyme (LZ) and lactoferrin (LF) in the uncinate process mucosa.
- To compare LZ and LF expression in healthy individuals versus chronic sinusitis patients.
- To analyze differences based on the presence or absence of nasal polyps.
Summary:
- Immunohistochemistry revealed strong LZ and LF staining in serous cells of submucosal glands in both normal and chronic sinusitis mucosa.
- LZ staining intensified in goblet cells (without polyps) and submucosal glands (with polyps) in sinusitis patients.
- LF staining was significantly stronger in patients with nasal polyps compared to controls.
Impact:
- Increased LZ and LF secretion by goblet cells and submucosal glands may contribute to mucosal defense in chronic sinusitis.
- Findings highlight the local protective mechanisms in the uncinate process.
- Provides insights into the pathophysiology of chronic sinusitis.
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