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Global Cross-Border Migration and Secondary Transmission Patterns of Lassa Fever - Global, 1969-2025
1Beijing Municipal Health Big Data and Policy Research Center, Beijing, China.
What Is Already Known About This Topic?:
Lassa fever has been increasingly transmitted from endemic West African regions via global migration; however, its macro-level transmission network and behavioral drivers remain uncharacterized.
What Is Added By This Report?:
We constructed a historical cross-border transmission network that revealed two distinct modes: air-travel-dependent intercontinental spread and land-dependent regional spread. Secondary human-to-human transmission is rare across all scenarios and relies critically on robust local infection prevention and control.
What Are The Implications For Public Health Practice?:
We recommend a shift from uniform border measures to precision- and scenario-based interventions. Enhancing targeted syndromic screening and local early warning capacities at the identified network hubs and bridge countries could optimize resource allocation and prevent outbreaks.
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