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Viral Tracing of Genetically Defined Neural Circuitry
Published on: October 17, 2012
Viral-based gene transfer to the mammalian CNS for functional genomic studies
C G Janson1, S W McPhee, P Leone
1CNG Gene Therapy Center, Jefferson Medical College, 1025 Walnut Street, Suite 511, Philadelphia, PA 19107, USA. cjanson@hotmail.com
Trends in Neurosciences
|November 24, 2001
Abstract:
A fundamental problem in neuroscience has been the creation of suitable in vivo model systems to study basic neurological phenomena and pathology of the central nervous system (CNS). Somatic cell genetic engineering with viral vectors provides a versatile tool to model normal brain physiology and a variety of neurological diseases.
