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Related Experiment Videos

SH2 domains, interaction modules and cellular wiring.

T Pawson1, G D Gish, P Nash

  • 1Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Canada. pawson@mshri.on.ca

Trends in Cell Biology
|November 24, 2001
PubMed
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Protein interaction modules, like SH2 domains, organize cellular behavior by transmitting signals. Rewiring these networks through pathogens or mutations can disrupt cell signaling and lead to disease.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Protein Interactions

Background:

  • SH2 domains are key protein-interaction modules involved in signal transduction.
  • Protein interactions are fundamental to organizing cellular behavior and responses.
  • Dysregulation of cellular signaling is implicated in various diseases.

Purpose of the Study:

  • To explore the role of protein-interaction modules in cellular signaling.
  • To discuss how alterations in cellular interaction networks contribute to disease.
  • To highlight the significance of SH2 domains as a model for protein modules.

Main Methods:

  • Literature review and conceptual analysis of protein-interaction networks.
  • Discussion of signaling pathways and molecular mechanisms.

Related Experiment Videos

  • Examination of the impact of pathogenic microorganisms and mutant proteins.

    • Main Results:

    • SH2 domains exemplify a class of modules crucial for signal transmission.
    • Protein interactions provide a general mechanism for cellular organization.
    • Rewiring of interaction networks can lead to dysregulated cell signaling.

    Conclusions:

    • Alterations in protein-interaction networks are a significant factor in disease pathogenesis.
    • Understanding these networks is vital for deciphering cellular dysfunction.
    • Pathogenic interference and genetic mutations can disrupt essential cellular communication.