Prostate brachytherapy: comparison of dose distribution with different 125I source designs

To evaluate the interchangeability of various commercially available iodine 125 ((125)I) sources and to assess the dosimetric effect of a change in source.

A modified peripherally loading prostate brachytherapy plan to deliver 145 Gy was devised by using a model (125)I source, which until recently was the only available (125)I source. A dose-volume histogram was generated. By using the available radial dose functions and anisotropy distributions for eight other currently commercially available sources, the same implant placement was planned and dose-volume histogram distributions tabulated. This exercise was performed for 15-, 45-, and 60-cm(3) glands. No implants were placed, and no physical radiation measurements were made. Dose calculations were theoretic: They were generated by using a widely available treatment planning system.

There was little difference in dose distribution to the volume receiving 100% of the prescribed dose (<6%); only one source showed a difference greater than 2%. Large differences, up to -40% to +60%, were seen in the volume of tissue encompassed within internal high-dose regions receiving 150% or 200% of the prescribed dose. These findings held true, irrespective of gland size, within a clinically relevant range (15-60 cm(3)) and for a uniformly loaded radionuclide distribution.

Reviewing only peripheral dose at or near the prescription dose of 145 Gy revealed little difference in doses for various source designs. Marked differences in high-dose regions were seen and may affect the dose received by internal sites. Effects of these changes on cure and/or complications remain speculative.