Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Valproate-induced encephalopathy.

W T Chen1, D J Yen, H Y Yu

  • 1Department of Neurology, The Neurological Institute, Taipei Veterans General Hospital, Taiwan, ROC.

Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed
|November 27, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Research progress on artificial intelligence-driven digital removable partial denture clinical diagnosis and treatment].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2026
Same author

[Study on the correlation between high expression of FHL1 in gastric cancer cells and cisplatin resistance].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2026
Same author

[Analysis of novel mutations in the SLC12A3 gene of a family with Gitelman syndrome].

Zhonghua nei ke za zhi·2026
Same author

[The clinical efficacy of unilateral biportal endoscopy contralateral inclinatory approach in the treatment of lumbar foraminal stenosis].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same author

[Effectiveness and safety of belumosudil in 20 patients with chronic graft-versus-host disease].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2025
Same author

[Analysis on new-type drugs use and related factors of high-risk behaviors in online-dating men who have sex with men in Shandong Province].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2025
Same journal

[[Protective action of biphenyl dimethyl dicarboxylate (DDB) against liver nuclear DNA damage induced by carcinogens]].

Zhonghua yi xue za zhi = Chinese medical journal; Free China ed·2018
Same journal

Aggressive natural killer cell lymphoma/leukemia.

Zhonghua yi xue za zhi = Chinese medical journal; Free China ed·2003
Same journal

Acute pancreatitis complicated with periappendicitis.

Zhonghua yi xue za zhi = Chinese medical journal; Free China ed·2003
Same journal

Hereditary hemorrhagic telangiectasia.

Zhonghua yi xue za zhi = Chinese medical journal; Free China ed·2003
Same journal

Segmental pancreatectomy for benign tumor of the pancreas.

Zhonghua yi xue za zhi = Chinese medical journal; Free China ed·2003
Same journal

In vitro growth inhibition by indomethacin on human oral squamous cell carcinoma lines synergistically suppressed by all-trans retinoic acid correlating to apoptosis.

Zhonghua yi xue za zhi = Chinese medical journal; Free China ed·2003
See all related articles

Valproate (VPA) add-on therapy for epilepsy can cause acute encephalopathy, even with prior safe VPA use. A high initial VPA dose may trigger this adverse reaction.

Area of Science:

  • Neurology
  • Clinical Pharmacology
  • Toxicology

Background:

  • Carbamazepine (CBZ) is a common antiepileptic drug.
  • Valproate (VPA) is frequently used as an add-on therapy for epilepsy.
  • Drug-induced encephalopathy is a potential adverse effect of antiepileptic medications.

Observation:

  • A 50-year-old woman on carbamazepine (CBZ) developed acute confusion after 10 days of valproate (VPA) add-on treatment.
  • The patient presented with elevated serum ammonia and EEG findings indicative of diffuse encephalopathy.
  • Serum levels of VPA and CBZ were within non-toxic ranges, and liver functions were normal.

Findings:

  • Discontinuation of VPA led to rapid clinical recovery.
  • Previous safe administration of VPA did not prevent the occurrence of encephalopathy in this case.

Related Experiment Videos

  • A high initial VPA dosage is suspected as the potential cause of the encephalopathy.

    • Implications:

    • Clinicians should be vigilant for signs of encephalopathy in patients receiving VPA, especially with high initial doses.
    • This case highlights that prior tolerance to VPA does not guarantee future safety.
    • Further investigation into dose-dependent VPA neurotoxicity is warranted.