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Nodulisporic acid A synthetic studies. 2. Construction of an eastern hemisphere subtarget
A B Smith1, Y S Cho, H Ishiyama
1Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. smithab@sas.upenn.edu
Organic Letters
|November 27, 2001
Abstract:
In this, the second of two Letters, we describe an effective assembly of (+)-4, an eastern hemisphere subtarget comprising the FGH rings of (+)-nodulisporic acid A (1) (17 steps, 9% overall yield). Central to the synthesis is a Koga three-component conjugate addition-alkylation sequence which secures the trans orientation of the vicinal quaternary methyl groups. [reaction: see text]