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Updated: Oct 3, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
Published on: June 9, 2023
Flavonoids: structural requirements for antiproliferative activity on breast cancer cells
C Pouget1, F Lauthier, A Simon
1UPRES EA 1085, 'Biomolécules et cibles cellulaires tumorales', Faculté de Pharmacie, 2 rue du Docteur Marcland, 87025 Cedex, Limoges, France.
Abstract:
Several classes of flavonoids (flavones, flavanones, 2'-hydroxychalcones and flavan-4-ols) having a variety of substituents on A ring were investigated for their antiproliferative activity against MCF-7 human breast cancer cells. Structure-activity relationships of these compounds were discussed. 2'-hydroxychalcones and methoxylated flavanones were found to be potent inhibitors of MCF-7 cells growth whereas flavones and flavan-4-ols appeared to be weak inhibitory agents except 7,8-dihydroxyflavone.
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