Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intravenous valproate in status epilepticus.

B M Hodges1, J E Mazur

  • 1Department of Clinical Pharmacy, School of Pharmacy, West Virginia University, Morgantown, USA.

The Annals of Pharmacotherapy
|November 29, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Relativistic Proton Spectrometer: A Review of Sensor Performance, Applications, and Science.

Space science reviews·2023
Same author

The Magnetic Electron Ion Spectrometer: A Review of On-Orbit Sensor Performance, Data, Operations, and Science.

Space science reviews·2021
Same author

A Revised Look at Relativistic Electrons in the Earth's Inner Radiation Zone and Slot Region.

Journal of geophysical research. Space physics·2019
Same author

Self-control choice with electrical stimulation of the brain as a reinforcer.

Behavioural processes·2014
Same author

Antimicrobial cycling: the future or a fad?

The Annals of pharmacotherapy·2001
Same author

Hyperbolic value addition and general models of animal choice.

Psychological review·2001
Same journal

Severe Phototoxic Skin Reaction Associated With Vandetanib: Implications for Pharmaceutical Care.

The Annals of pharmacotherapy·2026
Same journal

Efficacy and Safety of Oral PCSK9 Inhibitors in Adults With Hypercholesterolemia: An Updated Systematic Review and Meta-Analysis of RCTs.

The Annals of pharmacotherapy·2026
Same journal

RSVpreF: A Vaccine for the Respiratory Syncytial Virus.

The Annals of pharmacotherapy·2026
Same journal

Severe Acute Hepatitis Induced by Combined Rosuvastatin and Ticagrelor Therapy Post-PCI: The Challenges of Multi-Drug DILI Diagnosis.

The Annals of pharmacotherapy·2026
Same journal

Modified vs Full Lead-in Dose Apixaban and Rivaroxaban for Treatment of Acute Venous Thromboembolism.

The Annals of pharmacotherapy·2026
Same journal

A Comparison of Phenobarbital Dosing Strategies for the Treatment of Alcohol Withdrawal Syndrome.

The Annals of pharmacotherapy·2026
See all related articles

Intravenous valproate sodium (IV VPA) is not recommended as a first-line treatment for status epilepticus (SE). Limited data suggest it may be a later-line option when other therapies fail.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Status epilepticus (SE) is a neurological emergency requiring prompt treatment.
  • Established treatments for SE have limitations, prompting investigation into alternative agents.

Purpose of the Study:

  • To evaluate the efficacy and safety of intravenous valproate sodium (IV VPA) for treating status epilepticus (SE).

Main Methods:

  • A comprehensive literature search was conducted using MEDLINE (1966-July 2000) with keywords: valproate, valproic acid, and status epilepticus.
  • Bibliographies of relevant articles were reviewed for additional sources.

Main Results:

  • A review of existing medical literature assessed the safety and efficacy of IV VPA in SE treatment.
  • Current data on IV VPA for SE is limited.

Related Experiment Videos

Conclusions:

  • Experience with IV VPA in SE is insufficient to support its use as a first-line therapy.
  • IV VPA may be considered a third- or fourth-line treatment option for SE when first-line agents are ineffective or contraindicated.