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Effect of acetaminophen on atherosclerosis
P H Chong1, B Kezele, P J Pontikes
1Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, USA. cpang@tigger.cc.uic.edu
Objective:
To evaluate the antioxidant effects of acetaminophen in atherosclerosis.
Data Sources:
Experimental literature and abstracts accessed through MEDLINE (1966-February 2001).
Data Synthesis:
Atherosclerosis is an inflammatory disorder associated with coronary events. The oxidative stress burden resulting from excess pro-oxidant free radical formation contributes to oxidative modification of low-density lipoprotein (lipid peroxidation) and is associated with atherosclerosis. Acetaminophen (phenol-like compound) may limit these key processes that are involved. The findings of earlier experimental laboratory tests and abstracts are evaluated.
Conclusions:
In vitro data suggest that acetaminophen may reduce lipid peroxidation, whereas animal data showed decreased progression of atherosclerosis. Further animal model and human studies are required to confirm these earlier findings.