Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hexamitiasis in cadmium-exposed mice.

J H Exon, N M Patton, L D Koller

    Archives of Environmental Health
    |September 1, 1975
    PubMed
    Summary

    Cadmium exposure increased mortality in mice due to the parasite Hexamita muris. This suggests a synergistic effect between cadmium toxicity and hexamitiasis, impacting mouse health.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A review of the toxicology of acrylamide.

    Journal of toxicology and environmental health. Part B, Critical reviews·2007
    Same author

    Selenium toxicity in sheep grazing reclaimed phosphate mining sites.

    Veterinary and human toxicology·2003
    Same author

    Effects of sphingomyelin on aberrant colonic crypt foci development, colon crypt cell proliferation and immune function in an aging rat tumor model.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2003
    Same author

    Pathology of "toxic oils" and selected metals in the MRL/lpr mouse.

    Toxicologic pathology·2002
    Same author

    Multiple immune functions in rats fed Echinacea extracts.

    Immunopharmacology and immunotoxicology·2001
    Same author

    Effects of indole-3-carbinol on immune responses, aberrant crypt foci, and colonic crypt cell proliferation in rats.

    Journal of toxicology and environmental health. Part A·2001

    Area of Science:

    • Environmental Toxicology
    • Parasitology
    • Animal Health

    Background:

    • Cadmium is a toxic heavy metal with known adverse health effects.
    • Hexamita muris is an intestinal parasite that can affect rodents.

    Purpose of the Study:

    • To investigate the effect of cadmium exposure on mortality in mice.
    • To identify the causative agent of mortality in cadmium-exposed mice.
    • To explore potential interactions between cadmium and Hexamita muris.

    Main Methods:

    • Swiss Webster mice were exposed to 300 ppm or 3 ppm cadmium chloride in drinking water.
    • Mortality rates were recorded over a 4- to 5-week period.
    • Clinical signs and histopathology were used to determine the cause of death.

    Main Results:

    • Mice exposed to 300 ppm cadmium chloride exhibited 26% mortality, significantly higher than the 7% mortality in mice exposed to 3 ppm cadmium.
    • No mortality was observed in control mice.
    • Histopathological examination identified Hexamita muris as the causative agent of death; no direct cadmium-induced lesions were found.

    Conclusions:

    • Cadmium exposure, particularly at higher doses, significantly increases mortality in young mice.
    • Mortality in cadmium-exposed mice was attributed to hexamitiasis, suggesting a synergistic interaction between cadmium and Hexamita muris.
    • Cadmium may exacerbate the effects of Hexamita muris infection, leading to increased disease severity and mortality.

    Related Experiment Videos