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Mortality of patients with childhood onset (0-17 years) Type I diabetes in Israel: a population-based study

T Laron-Kenet1, I Shamis, S Weitzman

  • 1Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, Tel Aviv University, Israel.

Diabetologia
|November 29, 2001
PubMed

Insights

Children with Type I diabetes face significantly higher mortality rates. This study confirms increased mortality risk for childhood-onset diabetes compared to the general population.

Area of Science:

  • Endocrinology
  • Pediatrics
  • Epidemiology

Background:

  • Type I diabetes, also known as insulin-dependent diabetes, is a chronic condition.
  • Childhood-onset diabetes requires lifelong management and monitoring.

Purpose of the Study:

  • To investigate the mortality rate in individuals diagnosed with Type I diabetes during childhood in Israel.
  • To compare the mortality risk of this cohort with the general population.

Main Methods:

  • A nationwide cohort of 1,861 children and adolescents (0-17 years) diagnosed with Type I diabetes between 1965 and 1993 in Israel was analyzed.
  • Mortality data were tracked up to October 1996 with 100% ascertainment.

Main Results:

  • A total of 37 deaths occurred, revealing a significant excess mortality (p < 0.001) with a standard mortality ratio three times higher than the general population.
  • Leading causes of death included chronic diabetes complications (n=9), ketoacidosis (n=8), and infections (n=8).
  • Higher prevalence of nephropathy, neuropathy, and anemia was observed in females among those who died. 17 deceased patients had central nervous system diseases.

Conclusions:

  • Childhood-onset Type I diabetes is associated with a substantially increased risk of mortality.
  • These findings underscore the importance of comprehensive management and ongoing research for pediatric diabetes populations.
Abstract

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